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Article

Spatiotemporal rescue of memory dysfunction in Drosophila.

Science (New York, N.Y.) - 5 Dec 2003

McGuire Sean E, Le Phuong T, Osborn Alexander J, Matsumoto Kunihiro, Davis Ronald L

Abstract excerpt

We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect. The transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit, which rules out a developmental brain defect in the etiology of...

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Identifiers

PMID: 14657498
DOI: 10.1126/science.1089035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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