Article
Immunohistochemical and mutational analyses of beta-catenin, Ki-ras, and p53 in two subtypes of colorectal mucinous carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2003
Ikeda Satoshi, Shimizu Yosuke, Fujimori Masahiko, Ishizaki Yasuyo, Kurihara Takeshi, Ojima Yasutomo, Okajima Masazumi, Asahara Toshimasa
Abstract excerpt
PURPOSE: The adenoma-carcinoma sequence theory is accepted in carcinogenesis of colorectal carcinoma. To elucidate the nature and genetic alterations in colorectal mucinous carcinoma (MC), we analyzed clinical and pathological characteristics of colorectal MC and nonmucinous carcinoma (NMC), and, furthermore, we compared the prognoses and the statuses of the Wnt signaling pathway, Ki-ras, and p53 in these two...
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