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Article

Introducing transglycosylation activity into human salivary alpha-amylase (HSA).

Organic letters - 11 Dec 2003

Remenyik Judit, Ragunath Chandran, Ramasubbu Narayanan, Gyémánt Gyöngyi, Lipták András, Kandra Lili

Abstract excerpt

Synthesis of 4-nitrophenyl 1-thio-beta-D-maltoside, maltotrioside, and maltotetraoside in yields up to 60% has been achieved by a Tyr151Met (Y151M) mutant of human salivary alpha-amylase. Y151M is capable of transferring maltose and maltotriose residues from a maltotetraose donor onto different p-nitrophenyl glycosides. (1)H and (13)C NMR studies revealed that the mutated enzyme preserved the stereo- and...

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Identifiers

PMID: 14653701
DOI: 10.1021/ol035999k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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