Article
Is there a role for the IHH gene in Hirschsprung's disease?
Neurogastroenterology and motility - 1 Dec 2003
Garcia-Barceló M-M, Lee W-S, Sham M-H, Lui V C-H, Tam P K-H
Abstract excerpt
Hirschsprung disease (HSCR) is characterized by the absence of ganglion cells along a variable length of the intestine. HSCR has a complex genetic aetiology with 50% of the patients unexplained by mutations in the major HSCR genes. The Ihh gene is involved in the development of the enteric nervous system (ENS) and Ihh mutant mice present with a phenotype reminiscent of HSCR. The requirement of Ihh signalling for...
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