Article
Genetic variants of IL-11 associated with risk of Hirschsprung disease.
Neurogastroenterology and motility - 1 Oct 2015
Kim L H, Cheong H S, Shin J-G, Seo J-M, Kim D-Y, Oh J-T, Kim H-Y, Jung K, Koh I, Kim J-H, Shin H D
Abstract excerpt
BACKGROUND: Hirschsprung disease (HSCR) is a congenital and heterogeneous disorder characterized by the absence of enteric ganglia during enteric nervous system (ENS) development. Our recent genome-wide association study has identified a variant (rs6509940) of interleukin-11 (IL-11) as a potential susceptible locus for HSCR. As interleukins play important roles in the ENS, we further studied associations with...
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