Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'.

doi:10.1080/07853890310015181

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Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'.

Annals of medicine - 1 Jan 2003

Terwilliger Joseph D, Weiss Kenneth M

Abstract excerpt

Many promises have been made about the impact of the Human Genome Project on clinical practice and public health, yet despite massively funded efforts over the past decade, little headway has been made in elucidating the specific genetic factors which have major impact on the risk of developing common complex traits. There are two fundamental reasons for this abject failure as follows: 1) studies have been...

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