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Article

Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease.

Genes and immunity - 1 Dec 2003

Ban Y, Davies T F, Greenberg D A, Kissin A, Marder B, Murphy B, Concepcion E S, Villanueva R B, Barbesino G, Ling V, Tomer Y

Abstract excerpt

The cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene on 2q33 is associated with autoimmune thyroid diseases (AITDs). Our earlier study in 56 families showed linkage of 2q33 to the presence of thyroid antibodies (TAbs). The goals of this study were to confirm the linkage of the 2q33 regio...

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Share to Antigens, Differentiation
Share to Antigens, Differentiation, T-Lymphocyte
Share to CD28 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 2

Share to CTLA-4 Antigen

Share to Inducible T-Cell Co-Stimulator Protein

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Share to Thyroiditis, Autoimmune

Source

Identifiers

PMID: 14647199
DOI: 10.1038/sj.gene.6364018

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14647199-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease.PMID 14647199Read ↗

CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production.Semantic proximity Read ↗

Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases.Semantic proximity Read ↗

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Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.Semantic proximity Read ↗

Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28.Semantic proximity Read ↗

Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.Semantic proximity Read ↗

Genetic association of coeliac disease susceptibility to polymorphisms in the ICOS gene on chromosome 2q33.Semantic proximity Read ↗

Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.Semantic proximity Read ↗

'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease.Semantic proximity Read ↗

A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease.Semantic proximity Read ↗

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