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Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus

28 Nov 2003

Abstract excerpt

Vancomycin is usually reserved for treatment of serious infections, including those caused by multidrug-resistant Staphylococcus aureus. A clinical isolate of S. aureus with high-level resistance to vancomycin (minimal inhibitory concentration = 1024 microg/ml) was isolated in June 2002. This isolate harbored a 57.9-kilobase multiresistance conjugative plasmid within which Tn1546 (vanA) was integrated. Additional...

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PMID: 14645850
DOI: 10.1126/science.1090956

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