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Article

Effect of N-terminal and Met23 mutations on the structure and dynamics of onconase.

The Journal of biological chemistry - 13 Feb 2004

Gorbatyuk Vitaliy Y, Tsai Cheng-Kun, Chang Chi-Fon, Huang Tai-huang

Abstract excerpt

Onconase (rONC), otherwise known as ranpirnase or P-30 protein, which was initially purified from extracts of Rana pipiens oocytes and early embryos, exhibits anticancer activity both in vitro and in vivo and is in phase III clinical trials for tumor therapy. We have determined the solution NMR structure of a recombinant onconase with Met(-1), Gln1, and Leu23 residues (M-1, Q1, M23L)rONC. The 20 best solution...

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PMID: 14645226
DOI: 10.1074/jbc.M311233200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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