Article
Mutations in GYPB exon 5 drive the S-s-U+(var) phenotype in persons of African descent: implications for transfusion.
Transfusion - 1 Dec 2003
Storry Jill R, Reid Marion E, Fetics Susan, Huang Cheng-Han
Abstract excerpt
BACKGROUND: The S-s-U- phenotype in African Americans is due to a GYPB deletion, however the molecular basis for the S-s-U+var phenotype is poorly understood. Variable reactivity of S-s-U+var RBCs with monoclonal anti-He or by anti-U has been demonstrated, however the underlying molecular bases for this phenotype remain to be established. STUDY DESIGN AND METHODS: Hemagglutination was performed on 104 S-s- blood...
Topics
- Black or African American
- Alleles
- Base Sequence
- Blood Transfusion
- Exons
- Glycophorins
- Humans
- MNSs Blood-Group System
- Membrane Glycoproteins
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Sequence Analysis, DNA
- Sialoglycoproteins