Antibody to Genome‐Derived Neisserial Antigen 2132, a<i>Neisseria meningitidis</i>Candidate Vaccine, Confers Protection against Bacteremia in the Absence of Complement‐Mediated Bactericidal Activity

Abstract excerpt

Genome-derived neisserial antigen 2132 (GNA2132) is a novel vaccine candidate that was identified during the Neisseria meningitidis group B strain MC58 genome-sequencing project. To assess the vaccine potential of GNA2132, we prepared antisera from mice immunized with recombinant GNA2132 (gene from strain NZ394/98). Anti-GNA2132 antibody bound to the surface of live bacteria from all 7 capsular group B or C...

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