Article
Psoriasis susceptibility locus on 18p revealed by genome scan in Finnish families not associated with PSORS1.
The Journal of investigative dermatology - 1 Oct 2003
Asumalahti Kati, Laitinen Tarja, Lahermo Päivi, Suomela Sari, Itkonen-Vatjus Raija, Jansen Christer, Karvonen Jaakko, Karvonen Seija-Liisa, Reunala Timo, Snellman Erna, Uurasmaa Tutta, Saarialho-Kere Ulpu, Kere Juha
Abstract excerpt
The major susceptibility locus for psoriasis, PSORS1, resides on chromosome 6p and includes the candidate genes HLA-C, HCR, and CDSN. Based on a nationwide collection of psoriasis patients and genotyping for the PSORS1 susceptibility haplotype, we selected for a genome scan nine families who do not show association with PSORS1 to more easily detect minor loci for psoriasis susceptibility. In the genome scan, five...
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