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Article

A common mutation, Arg457-->Gln, links prothrombin deficiencies in the Puerto Rican population.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2003

Lefkowitz J B, Weller A, Nuss R, Santiago-Borrero P J, Brown D L, Ortiz I R

Abstract excerpt

Five unrelated families with Puerto Rican ancestry were identified as having at least one member with bleeding due to a prothrombin deficiency. Genetic prothrombin deficiencies are extremely rare, but at the University of Puerto Rico Hemophilia Center, prothrombin deficiency is the third most common congenital coagulation factor deficiency. Because Puerto Rico is relatively isolated, there was a reasonable...

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PMID: 14629473
DOI: 10.1046/j.1538-7836.2003.00420.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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