Article
Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed nets.
The American journal of tropical medicine and hygiene - 1 Sept 2003
Alifrangis Michael, Lemnge Martha M, Rønn Anita M, Segeja Method D, Magesa Stephen M, Khalil Insaf F, Bygbjerg Ib C
Abstract excerpt
In Magoda and Mpapayu villages in Tanzania, we have previously found comparable high prevalence of Plasmodium falciparum resistance to sulfadoxine/pyrimethamine (S/P) in vivo and of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes of P. falciparum responsible for resistance to S/P. In December 1998, Magoda received insecticide-treated nets (ITNs), whereas ITNs were...
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