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Article

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.

The Journal of experimental medicine - 18 Aug 2003

Paloneva Juha, Mandelin Jami, Kiialainen Anna, Bohling Tom, Prudlo Johannes, Hakola Panu, Haltia Matti, Konttinen Yrjo T, Peltonen Leena

Abstract excerpt

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), Nasu-Hakola disease, is a globally distributed recessively inherited disease. PLOSL is characterized by cystic bone lesions, osteoporotic features, and loss of white matter in the brain leading to spontaneous bone fractures and profound presenile dementia. We have earlier characterized the molecular genetic background of PLOSL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12925681
DOI: 10.1084/jem.20030027
PMCID: PMC2194176

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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