Article
Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein.
Clinical endocrinology - 1 Nov 2003
Kim Kyongsong, Sanno Naoko, Arai Keiko, Takano Koji, Yasufuku-Takano Junko, Teramoto Akira, Shibasaki Tamotsu
Abstract excerpt
OBJECTIVE: Ghrelin and its receptor, growth hormone secretagogue (GHS) receptor (GHSR), are expressed in the normal pituitary gland and various types of pituitary adenoma. Somatic mutations in the subunit of Gs alpha protein (gsp), which led to a constitutive activation of adenylyl cyclase, are r...
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