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Pseudogenes: are they "junk" or functional DNA?

Annual review of genetics - 1 Jan 2003

Balakirev Evgeniy S, Ayala Francisco J

Abstract excerpt

Pseudogenes have been defined as nonfunctional sequences of genomic DNA originally derived from functional genes. It is therefore assumed that all pseudogene mutations are selectively neutral and have equal probability to become fixed in the population. Rather, pseudogenes that have been suitably investigated often exhibit functional roles, such as gene expression, gene regulation, generation of genetic...

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PMID: 14616058
DOI: 10.1146/annurev.genet.37.040103.103949

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