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Article

Induction of cell death of gastric cancer cells by a modified compound of the annonaceous acetogenin family.

Chembiochem : a European journal of chemical biology - 7 Nov 2003

Huang Guo-Rui, Jiang Sheng, Wu Yu-Lin, Jin Yan, Yao Zhu-Jun, Wu Jia-Rui

Abstract excerpt

Annonaceous acetogenins are a family of natural products with antitumor activities. The polyether mimic AA005 has been synthesized. The cytotoxic mechanism of AA005 was investigated. It was found that AA005 can induce the cell death of gastric tumor cells. Most AA005-induced cell death is due to necrosis but partial and p53-independent apoptosis is also detected. An expanded study with gastric tumor cells and a...

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Identifiers

PMID: 14613114
DOI: 10.1002/cbic.200300677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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