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Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution.

Cellular immunology - 1 Aug 2003

Abdel-Wahab Zeinab, Kalady Matthew F, Emani Sirisha, Onaitis Mark W, Abdel-Wahab Omar I, Cisco Robin, Wheless Lee, Cheng Tsung-Yen, Tyler Douglas S, Pruitt Scott K

Abstract excerpt

Modification of the parental immunodominant Melan-A/MART-1 peptide (MART-1(26-35)) by replacing the alanine with leucine (A27L) enhances its immunogenicity. Because of the reported advantages of RNA over peptides in DC vaccines, we sought to mutate the MART-1 gene to encode a full-length MART-1 antigen with an A27L amino acid substitution. Human DC were transfected with A27L-mutated MART-1 RNA (A27L RNA) or...

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PMID: 14609574
DOI: 10.1016/j.cellimm.2003.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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