Article
Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination.
Blood - 1 Mar 2004
Stebbing Justin, Gazzard Brian, Patterson Steve, Bower Mark, Perumal Dhayaneethie, Nelson Mark, McMichael Andrew, Ogg Graham, Epenetos Agamemnon, Gotch Frances, Savage Philip
Abstract excerpt
The ability of therapeutic vaccines to generate large numbers of CD8+ T lymphocytes that have specificity for HIV-1 or other virally infected cells has enormous potential clinical value. However, approaches to produce cytotoxic T lymphocytes (CTLs) in vivo via vaccine technology have thus far been disappointing and the ex vivo production of cells for adoptive transfer is labor intensive and expensive. We describe...
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