Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.

doi:10.1128/jb.174.24.8081-8093.1992

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Article

Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.

Journal of bacteriology - 1 Dec 1992

Hansson M, Hederstedt L

Abstract excerpt

Mutations that cause a block in a late step of the protoheme IX biosynthetic pathway, i.e., in a step after uroporphyrinogen III, map at 94 degrees on the Bacillus subtilis chromosomal genetic map. We have cloned and sequenced the hem genes at this location. The sequenced region contains six open reading frames: ponA, hemE, hemH, hemY, ORFA, and ORFB. The ponA gene product shows over 30% sequence identity to...

Topics

Amino Acid Sequence
Animals
Bacillus subtilis
Bacterial Proteins
Base Sequence
Blotting, Northern
Carrier Proteins
Cloning, Molecular
DNA, Bacterial
Ferrochelatase
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heme

Hexosyltransferases

Humans

Molecular Sequence Data

Multienzyme Complexes

Multigene Family

Muramoylpentapeptide Carboxypeptidase

Source

Open in PubMed Open full text

Identifiers

PMID: 1459957
DOI: 10.1128/jb.174.24.8081-8093.1992
PMCID: PMC207547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1459957-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.PMID 1459957Read ↗

Bacillus subtilis HemY is a peripheral membrane protein essential for protoheme IX synthesis which can oxidize coproporphyrinogen III and protoporphyrinogen IX.Semantic proximity Read ↗

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