Article
Characterization of a hemA/hemE mutant of E. coli and regulation of hemE.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 1994
Pido S, Tsoi K W, Umanoff H, Cosloy S D, Russell C S
Abstract excerpt
Uroporphyrinogen III is the committed intermediate common to heme and siroheme biosynthesis in E. coli. Uroporphyrinogen III decarboxylase is the first enzyme at the branch point which commits to heme synthesis. A hemin-permeable hemA mutant which could grow on 5-aminolevulinic acid (ALA) or hemin, was mutagenized to give a double mutant, 10L2-1. The second mutation which was identified as hemE because it was...
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