Article
Langerhans cell histiocytosis patients have HLA Cw7 and DR4 types associated with specific clinical presentations and no increased frequency in polymorphisms of the tumor necrosis factor alpha promoter.
Medical and pediatric oncology - 1 Dec 2003
McClain Kenneth L, Laud Purnima, Wu Wen-Shu, Pollack Marilyn S
Abstract excerpt
BACKGROUND: Current theory on the etiology of Langerhans cell histiocytosis (LCH), formerly Histiocytosis-X, is that abnormality(ies) of the immune system are responsible for dysregulation of Langerhans cells (LC) in patients' lesions. Among the known abnormalities in LCH patients are increased a...
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