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Article

Genetic heterogeneity of the NS5A gene of hepatitis C virus and early response to interferon-alpha.

The Journal of infectious diseases - 1 Nov 2003

Boulestin Anne, Sandres-Saune Karine, Payen Jean-Louis, Rostaing Lionel, Pasquier Christophe, Izopet Jacques

Abstract excerpt

The double-stranded RNA-activated protein kinase-binding domain (PKRbd) of the NS5A gene of hepatitis C virus (HCV) was studied by the cloning and sequencing method, in HCV-infected patients who had a primary resistance to treatment with interferon (IFN)-alpha (early nonresponders). Patients whose virus load decreased by >or=0.5 log (early responders) were similarly analyzed. In the 2 groups, the PKRbd evolved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14593596
DOI: 10.1086/379037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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