Article
Genetic heterogeneity of prostatic carcinoma-derived cell lines as emphasized by DNA fingerprinting.
Electrophoresis - 1 Jan 2000
Bettink S, Wullich B, Christmann A, Zwergel T, Zang K D, Unteregger G
Abstract excerpt
To investigate genetic heterogeneity during in vitro cultivation of human prostatic carcinomas following radical prostatectomy we performed DNA fingerprinting using the digoxygenin-labeled probes (GACA)4 and (GTG)5. DNA was isolated from fresh material stemming from different areas within one tumor and from cell cultures of the same material. The patterns which were obtained by the nucleolar organizer region...
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