Article
Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Oct 2003
Janssen Anneleen, Gressens Pierre, Grabenbauer Markus, Baumgart Eveline, Schad Arno, Vanhorebeek Ilse, Brouwers Annelies, Declercq Peter E, Fahimi Dariush, Evrard Philippe, Schoonjans Luc, Collen Désiré, Carmeliet Peter, Mannaerts Guy, Van Veldhoven Paul, Baes Myriam
Abstract excerpt
Functional peroxisome deficiency, as encountered in Zellweger syndrome, causes a specific impairment of neuronal migration. Although the molecular mechanisms underlying the neuronal migration defect are at present unknown, the excess of very long chain fatty acids in brain, a consequence of peroxisomalbeta-oxidation deficiency, has often been hypothesized to play a major role. The purpose of the present study was...
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