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Article

Requirement of varicella-zoster virus immediate-early 4 protein for viral replication.

Journal of virology - 1 Nov 2003

Sato Bunji, Sommer Marvin, Ito Hideki, Arvin Ann M

Abstract excerpt

Varicella-zoster virus (VZV) is an alphaherpesvirus that causes two diseases, chickenpox and zoster. VZV open reading frame 4 (ORF4) encodes the immediate-early 4 (IE4) protein, which is conserved among alphaherpesvirus and has transactivation activity in transient transfections. To determine whether the ORF4 gene product is essential for viral replication, we used VZV cosmids to remove ORF4 from the VZV genome....

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Identifiers

PMID: 14581575
DOI: 10.1128/jvi.77.22.12369-12372.2003
PMCID: PMC254250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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