Article
Genetics of adrenocortical tumors: gatekeepers, landscapers and conductors in symphony.
Trends in endocrinology and metabolism: TEM - 1 Nov 2003
Stratakis Constantine A
Abstract excerpt
The genetic and histopathological backgrounds of adrenocortical tumorigenesis remain poorly characterized. In other tissues, there is conclusive evidence that hyperplasia and adenomas precede cancer. In the adrenal, there are few clinical cases of either hyperplasia or adenoma associated with later development of cancer, and there are few biological studies that attempt to characterize this process molecularly....
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