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Article

Calpain-1-dependent degradation of troponin I mutants found in familial hypertrophic cardiomyopathy.

Molecular and cellular biochemistry - 1 Sept 2003

Barta Judit, Tóth Attila, Jaquet Kornelia, Redlich Alexander, Edes István, Papp Zoltán

Abstract excerpt

The mechanism by which mutations of the cardiac troponin I (cTnI) gene evoke familial hypertrophic cardiomyopathy (fHCM) is unknown. In this investigation the potential effects of three fHCM-related cTnI mutations on Calpain-1-induced cTnI degradation were tested, and a study was made of whether...

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Source

Identifiers

PMID: 14575308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14575308-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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