Article
High detection rate for BRCA2 mutations in male breast cancer families from North West England.
Familial cancer - 1 Jan 2001
Evans D G, Bulman M, Young K, Gokhale D, Lalloo F
Abstract excerpt
33 families with a history of male breast cancer aged 60 or less or with a family history of male and female breast cancer were screened for the presence of BRCA2 mutations. 12 pathogenic BRCA2 mutations were identified (36%) in samples from an affected family member. All mutations segregated with disease where it was possible to check. Of the 14 families fulfilling BCLC criteria, 9 (64%) had mutations whilst...
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