Article
Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair.
The Journal of cell biology - 27 Oct 2003
Wong Pauline, Coulombe Pierre A
Abstract excerpt
The ability to heal wounds is vital to all organisms. In mammalian tissues, alterations in intermediate filament (IF) gene expression represent an early reaction of cells surviving injury. We investigated the role of keratin IFs during the epithelialization of skin wounds using a keratin 6alpha and 6beta (K6alpha/K6beta)-null mouse model. In skin explant culture, null keratinocytes exhibit an enhanced...
Topics
Join the communities discussing this publication.