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Article

The IDDM-associated solitary retroviral promoters DQ-LTR3 and DQ-LTR13 have a distinct impact on the expression of selected DQB1 genes in different cell lines in vitro.

Immunogenetics - 1 Nov 2003

Krach Katrin, Badenhoop Klaus, Tönjes Ralf R

Abstract excerpt

The HLA complex on chromosome 6, especially of the HLA class II genes, plays an important role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Three solitary long terminal repeats (LTRs) have been described in the vicinity of HLA DQ, two of them modifying the genetic susceptibility to type 1 diabetes on high-risk HLA DQ haplotypes. Therefore, we have investigated the putative regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endogenous Retroviruses

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 14566435
DOI: 10.1007/s00251-003-0614-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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