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Article

The cardioprotective agent urocortin induces expression of CT-1.

Cardiovascular toxicology - 1 Jan 2003

Janjua Sadia, Lawrence Kevin M, Ng Leong L, Latchman David S

Abstract excerpt

The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathways, but the protective effect of Ucn requires de novo protein synthesis whereas that of CT-1 does...

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Identifiers

PMID: 14555790
DOI: 10.1385/ct:3:3:255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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