Article
[Relationship between the HBV core gene mutation and the cellular immunity in host].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Sept 2003
Li Jia, Zhu Li-min, Liang Shu-ren, Li Shun-tian, Xu Jian
Abstract excerpt
OBJECTIVES: To study the relationship between the mutation of Leu60Val in HBV core region and the cellular immunity in patients with chronic hepatitis B (CHB). METHODS: HBV DNA C gene mutation was confirmed by polymerase chain reaction (PCR) and sequencing the products directly. The cytokines (IFN-gamma, TNF-alpha and IL-2) levels in serum were measured by enzyme linked immunosorbent assay (ELISA). The...
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