Article
Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy.
Bulletin of experimental biology and medicine - 1 Jul 2003
Yarygin V N, Sukhikh G T, Sitnikov V F, Stenina M A, Kuznetsov A B, Poltavtseva R A, Krivov L I, Voevodin D A, Savchuk V I, Revishchin A V, Korochkin L I, Aleksandrova M A
Abstract excerpt
Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after transplantation. Our results indicate that xenogeneic transplantation of embryonic myogenic...
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