Sequence alignments and pair hidden Markov models using evolutionary history.

Abstract excerpt

This work presents a novel pairwise statistical alignment method based on an explicit evolutionary model of insertions and deletions (indels). Indel events of any length are possible according to a geometric distribution. The geometric distribution parameter, the indel rate, and the evolutionary time are all maximum likelihood estimated from the sequences being aligned. Probability calculations are done using a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Biological Evolution
• Share to Computational Biology