Article
Self-assembly of proteins into designed networks.
Science (New York, N.Y.) - 3 Oct 2003
Ringler Philippe, Schulz Georg E
Abstract excerpt
A C4-symmetric tetrameric aldolase was used to produce a quadratic network consisting of the enzyme as a rigid four-way connector and stiff streptavidin rods as spacers. Each aldolase subunit was furnished with a His6 tag for oriented binding to a planar surface and two tethered biotins for binding streptavidin in an oriented manner. The networks were improved by starting with composite units and also by binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.