Article
Genotypes from patients indicate no paternal mitochondrial DNA contribution.
Annals of neurology - 1 Oct 2003
Taylor Robert W, McDonnell Martina T, Blakely Emma L, Chinnery Patrick F, Taylor Geoffrey A, Howell Neil, Zeviani Massimo, Briem Egill, Carrara Franco, Turnbull Douglass M
Abstract excerpt
A cornerstone of mitochondrial genetics, strict maternal inheritance, has been challenged recently by the study of a patient with mitochondrial myopathy due to a sporadic 2bp deletion. The mitochondrial DNA (mtDNA) harboring the mutation was paternal in origin, whereas the patient's blood was ide...
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