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Article

Paternal Inheritance of Mitochondrial DNA

22 Aug 2002

Abstract excerpt

This report describes a 28-year-old man with lifelong exercise intolerance. Evaluation revealed a mitochondrial myopathy due to a novel 2-bp mitochondrial DNA deletion in the ND2 gene, which codes for a subunit of enzyme complex I of the mitochondrial respiratory chain. Studies of the patient and his immediate family members revealed that the abnormal mitochondrial DNA was paternal in origin and accounted for 90...

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Identifiers

PMID: 12192017
DOI: 10.1056/nejmoa020350

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