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Article

Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically.

Biological & pharmaceutical bulletin - 1 Oct 2003

Shibata Hirofumi, Shirakata Chikako, Kawasaki Hiromi, Sato Yoichi, Kuwahara Tomomi, Ohnishi Yoshinari, Arakaki Naokatu, Higuti Tomihiko

Abstract excerpt

Flavone and its derivatives had very weak antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus, but dramatically intensified MRSA's susceptibility to beta-lactams. We named these compounds "ILSMR (intensifier of beta-lactam-susceptibility...

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Source

Identifiers

PMID: 14519958
DOI: 10.1248/bpb.26.1478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14519958-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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