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Article

Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases.

The Journal of biological chemistry - 12 Dec 2003

Bernard Delphine G, Gabilly Stéphane T, Dujardin Geneviève, Merchant Sabeeha, Hamel Patrice P

Abstract excerpt

Heme attachment to the apoforms of fungal mitochondrial cytochrome c and c1 requires the activity of cytochrome c and c1 heme lyases (CCHL and CC1HL), which are enzymes with distinct substrate specificity. However, the presence of a single heme lyase in higher eukaryotes is suggestive of broader substrate specificity. Here, we demonstrate that yeast CCHL is active toward the non-cognate substrate apocytochrome...

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PMID: 14514677
DOI: 10.1074/jbc.M308881200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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