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Article

Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes.

The Journal of biological chemistry - 2 Dec 2005

Bernard Delphine G, Quevillon-Cheruel Sophie, Merchant Sabeeha, Guiard Bernard, Hamel Patrice P

Abstract excerpt

Mitochondrial apocytochrome c and c1 are converted to their holoforms in the intermembrane space by attachment of heme to the cysteines of the CXXCH motif through the activity of assembly factors cytochrome c heme lyase and cytochrome c1 heme lyase (CCHL and CC1HL). The maintenance of apocytochrome sulfhydryls and heme substrates in a reduced state is critical for the ligation of heme. Factors that control the...

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Identifiers

PMID: 16207709
DOI: 10.1074/jbc.M508574200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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