Differential activities of bacteriophage depolymerase on bacterial polysaccharide: binding is essential but degradation is inhibitory in phage infection of K1-defective Escherichia coli.

doi:10.1128/jb.174.23.7757-7761.1992

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Article

Differential activities of bacteriophage depolymerase on bacterial polysaccharide: binding is essential but degradation is inhibitory in phage infection of K1-defective Escherichia coli.

Journal of bacteriology - 1 Dec 1992

Pelkonen S, Aalto J, Finne J

Abstract excerpt

Host range mutants were derived from bacteriophages PK1A and PK1E specific for the K1 polysialic acid capsule of Escherichia coli. The mutants were selected for their ability to infect E. coli bacteria with a low level of the K1 capsule. A specific loss of the cleaving activity of the phage endos...

Topics

Bacterial Capsules
Coliphages
Glycoside Hydrolases
Mutation
Polysaccharides, Bacterial
Receptors, Virus
Sialic Acids
Substrate Specificity

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