Article

Genetic determinants of host tropism in <i>Klebsiella</i> phages

2022-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Bacteriophages play key roles in bacterial ecology and evolution and are potential antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we used 46 newly-isolated phages to challenge 138 representative clinical isolates of Klebsiella pneumoniae , a widespread opportunistic pathogen. Spot tests revealed a narrow host range for most phages, with <2% of 6319 pha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c228963-61c7-5524-97ba-2738f7940db8
DOI: 10.1101/2022.06.01.494021

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of host tropism in <i>Klebsiella</i> phagesDOI 10.1101/2022.06.01.494021Read

Targeted phage hunting to specific <i>Klebsiella pneumoniae</i> clinical isolates is an efficient antibiotic resistance and infection control strategySemantic proximity Read

Isolation and characterisation of <i>Klebsiella</i> phages for phage therapySemantic proximity Read

Evolutionary strategies of <i>Klebsiella</i> phages in a host-diverse environmentSemantic proximity Read

Bacteriophages of <i>Klebsiella</i> spp., their diversity and potential therapeutic usesSemantic proximity Read

Genomic Characterization of 30 Lytic <i>Klebsiella pneumoniae</i> BacteriophagesSemantic proximity Read

Harnessing Lytic Phages for Biofilm Control in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Causing Urinary Tract InfectionSemantic proximity Read

Isolation and characterization of three lytic podo-bacteriophages with two receptor recognition modules against multidrug-resistant <i>Klebsiella pneumoniae</i>Semantic proximity Read

Molecular analysis of the interactions between phages and the bacterial host <i>Klebsiella pneumoniae</i>Semantic proximity Read

Phenotypic and genomic features shaping the activity of a novel T4-like phage against clinical multidrug-resistant Klebsiella pneumoniaeSemantic proximity Read

Isolation and characterization of novel phages targeting pathogenic <i>Klebsiella pneumoniae</i>Semantic proximity Read

Genomic characterization of four novel bacteriophages infecting the clinical pathogen <i>Klebsiella pneumoniae</i>Semantic proximity Read

Environmental differences impact <i>Acinetobacter baumannii</i> phage isolation and infectivitySemantic proximity Read