Article
Evidence for the localization of a malignant hyperthermia susceptibility locus (MHS2) to human chromosome 17q.
Genomics - 1 Nov 1992
Levitt R C, Olckers A, Meyers S, Fletcher J E, Rosenberg H, Isaacs H, Meyers D A
Abstract excerpt
Malignant hyperthermia susceptibility is a lethal autosomal dominant disorder of skeletal muscle metabolism that is triggered by all potent inhalation anesthetic gases. Recent linkage studies suggest a genetic locus for this disorder on 19q13.1. We have previously reported three unrelated families diagnosed with MHS that are unlinked to markers surrounding this locus on 19q13.1. In this report we extend these...
Topics
- Adult
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Malignant Hyperthermia
- Middle Aged