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Article

Evidence for genetic heterogeneity in malignant hyperthermia susceptibility.

Genomics - 1 Nov 1991

Levitt R C, Nouri N, Jedlicka A E, McKusick V A, Marks A R, Shutack J G, Fletcher J E, Rosenberg H, Meyers D A

Abstract excerpt

Malignant hyperthermia susceptibility (MHS) is a clinically heterogeneous pharmacogenetic disorder characterized by accelerated metabolism, hyperthermia, and frequently muscle rigidity. MHS is elicited by all commonly used potent inhalation anesthetics and depolarizing neuromuscular blockers and remains an important cause of death due to anesthesia. Recent linkage studies suggest a single genetic locus for this...

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PMID: 1774061
DOI: 10.1016/0888-7543(91)90061-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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