Article
Two new HLA DRB1 alleles found in African Americans: implications for balancing selection at positions 57 and 86.
Tissue antigens - 1 Aug 1992
Apple R J, Erlich H A
Abstract excerpt
Two new DRB1 alleles have been identified (DRB1*0303 and DRB1*0805) in African Americans that differ from known DRB1 alleles only by a glycine to valine exchange at position 86. The novel DRB1*0303 allele, found in one individual, has the same DQA1*0401-DQB1*04 haplotype as DRB1*0302, suggesting that it may be a recent diversification of *0302. The novel DRB1*0805 allele, identified in 4 individuals, was found on...
Topics
- Africa
- Alleles
- Amino Acid Sequence
- Base Sequence
- Black People
- DNA
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Molecular Sequence Data