DQB1*0202 and the new DQB1*0203 allele: a fourth pair of DQB1 alleles differing only at codon 57.

doi:10.1111/j.1399-0039.1997.tb02750.x

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Article

DQB10202 and the new DQB10203 allele: a fourth pair of DQB1 alleles differing only at codon 57.

Tissue antigens - 1 Mar 1997

Olerup O, Aldener-Cannavá A, Fogdell-Hahn A, Getty R R, Wagenknecht D R, McIntyre J A

Abstract excerpt

Amino acid 57 of DQ beta chains is of functional importance as it influences peptide binding, is part of B and T cell epitopes, and is associated with susceptibility and resistance to insulin-dependent diabetes mellitus and humoral immunodeficiencies. Polymorphism of codon 57 is conserved in prim...

Topics

Alleles
Base Sequence
Codon
DNA, Complementary
Exons
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Molecular Sequence Data
Sequence Homology, Nucleic Acid

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