DRB1*1316: evolutionary and functional implications of a novel polymorphism at codon 86.

doi:10.1016/0198-8859(95)00107-7

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Article

DRB1*1316: evolutionary and functional implications of a novel polymorphism at codon 86.

Human immunology - 1 Jan 1996

Dinauer D M, Glumm R, Baxter-Lowe L A

Abstract excerpt

HLA-DRB1 molecules contain extensive polymorphism localized to specific functional regions of the antigen binding site (ABS). Position 86 of HLA-DRB1 molecules modulates a hydrophobic pocket in the ABS which acts as a peptide anchoring site [1]. We report the nucleotide sequence of HLA-DRB1*1316...

Topics

Alleles
Animals
Aspartic Acid
Base Sequence
Codon
Evolution, Molecular
Glycine
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Models, Molecular
Molecular Sequence Data
Polymorphism, Genetic
Primates
Valine

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