Article
[Athymic mice of the 101/HY strain with a new allele at the nude locus].
Biulleten' eksperimental'noi biologii i meditsiny - 1 Jan 1992
Ignat'eva E L, Malashenko A M
Abstract excerpt
The spontaneous autosomal recessive mutation at locus nude (nuY) was discovered in 101/HY mice imperfect in respect to repair of induced chromosome damage and this is maintained in conventional conditions at RLEBM. Homozygous mutants have no hair and thymic differentiation. The new mutant form can be a valuable model for medical and biological experiments requiring T-cell immune deficiency.
Topics
- Alleles
- Animals
- Chromosome Mapping
- Immunologic Deficiency Syndromes
- Male
- Mice
- Mice, Nude
- Mutation
- T-Lymphocytes